Therapeutic applications of genetic code expansion
نویسندگان
چکیده
منابع مشابه
Genetic Code Expansion and Optoproteomics
Nature has invented photoreceptor proteins that are involved in sensing and response to light in living organisms. Genetic code expansion (GCE) technology has provided new tools to transform light insensitive proteins into novel photoreceptor proteins. It is achieved by the site-specific incorporation of unnatural amino acids (Uaas) that carry light sensitive moieties serving as "pigments" that...
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Despite the fact that the genetic code is known to vary between organisms in rare cases, it is believed that in the lifetime of a single cell the code is stable. We found Acetohalobium arabaticum cells grown on pyruvate genetically encode 20 amino acids, but in the presence of trimethylamine (TMA), A. arabaticum dynamically expands its genetic code to 21 amino acids including pyrrolysine (Pyl)....
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1Department of Chemistry, Indian Institute of Technology Guwahati, Gumahati 781039, India 2Department of Chemistry and Center for Cell & Genome Science, The University of Utah, Salt Lake City, UT 84112, USA 3Department of Chemical Biology and Applied Chemistry, School of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan 4Department of Chemistry, Roy and Diana Vagelos Laboratori...
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ژورنال
عنوان ژورنال: SCIENTIA SINICA Chimica
سال: 2018
ISSN: 1674-7224
DOI: 10.1360/n032018-00071